Synthesis, Characterization and Antitumor Activity of Some Novel Pyrimidine Sulfonamide Derivatives

The key intermediate in this study is synthesis of pyrimidine-5-sulfonamides 2a,b.

Further modification of starting material by treatment with ethanolamine, anthranilic acid and 3-bromopropanoic acid yielded the condensed pyrimidine derivatives incorporating sulfonamide moiety such as: imidazopyrimidine 3a,b, pyrimidoquinazoline 4a,b and pyrimidothiazine derivatives 5a,b, respectively, in good yields.

S-Methylpyrimidine derivatives 6a,b were obtained and let to react either with morpholine and with phosphorous oxychloride to give 7a,b or 8a,b respectively.

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Corrosion Inhibition Efficiency of Fenugreek Leaves Extract on Mild Steel Surface in Acidic Medium

Corrosion is the deterioration of metal by the chemical reaction when the metals come in contact with the atmosphere or moisture.

Steel is used widely as a metal or alloy in various industrial applications and acid solutions are used in many industrial processes such as acid cleaning and acid descaling etc.

Corrosion of steel in acidic medium is common phenomena. Generally the generation of metals is from ores or the compounds which occur naturally with very high energy or large amount of energy.

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Antifungal Activities of Β-Ionone, Carvone and 1,8-Cineole Essential Oil Components Against Aspergillus niger Spores

Many substances have been reported as antibacterial agents and some as antifungal in the scientific literature. The aim of this study was to evaluate the antifungal potential of three main compounds of essential oils, β-Ionone; carvone and 1,8-cineole, against the growth of spores of Aspergillus niger strain.

For that purpose, the spores of the studied strain were exposed to successive concentrations of these three compounds to determine their minimum inhibitory (MIC) and fungicidal (MFC) concentrations against this pathogenic strain by the microdilution method using the 96 well microtiter plates.

The obtained results have shown the capacity of three compounds to inhibit the growth of A. niger spores with low values of CMIs determined for β-Ionone (2.5%), carvone (0.625%) and 1,8cineole (1.25%).

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