The key intermediate in this study is
synthesis of pyrimidine-5-sulfonamides 2a,b.
Further modification of starting material by
treatment with ethanolamine, anthranilic acid and 3-bromopropanoic acid yielded
the condensed pyrimidine derivatives incorporating sulfonamide moiety such as:
imidazopyrimidine 3a,b, pyrimidoquinazoline 4a,b and pyrimidothiazine
derivatives 5a,b, respectively, in good yields.
S-Methylpyrimidine derivatives 6a,b were
obtained and let to react either with morpholine and with phosphorous
oxychloride to give 7a,b or 8a,b respectively.
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