Wednesday, 5 July 2017

Molecular Docking Studies of Quinones against Human Inducible Nitric Oxide Synthase

QuinonesQuinones represent an important class of naturally occurring compounds that are present in flowering plants, bacteria and fungi, primarily as essential components of the electron-transport chains involved in photosynthesis and cellular respiration.

There are various kinds of biological activities such as antineoplastic, antimalarial, antitumor, anticoagulant, herbicidal and antibiotic attributable to this group of compounds including their derivatives.

Synthetic or natural quinoid compounds such as 1, 4-benzoquinone and 1, 4-naphthoquinone have been used as dyes. Some quinones are widely applied in the fields of photochemistry, co-ordination chemistry and synthetic chemistry.

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Synthesis, Characterization and Antitumor Activity of Some Novel Pyrimidine Sulfonamide Derivatives

The key intermediate in this study is synthesis of pyrimidine-5-sulfonamides 2a,b. Further modification of starting material by tr...