The present study was designed to evaluate the
effects of oral administration of the fisetin on lung tumour initiation by
orally applied Benzo(a)pyrene (B(a) P).
Its effects on biochemical markers enzymes as
well as pathological markers were evaluated. The pathological enzyme activities
were increased (P<0.05) in lung
cancer bearing animals when compared with control group animals.
Fisetin-treated animals from groups-3 and- 4
showed a significant (P<0.05) decreases in the levels of these enzymes when
compared to B(a)P induced group-2 animals. Levels of glycoprotein and
activities of membrane ATPases play an important role in the carcinogenesis.
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